Apr 14, 2011


Report says 7,000 babies stillborn every day worldwide

A pregnant mother is examined in a clinicBetter clinical care and monitoring could cut the number of stillbirths worldwide, say the authors

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Around 7,000 stillbirths occur globally every day, with the poorest nations worst affected, a series of papers published inThe Lancet suggest.
An overwhelming 98% of the 2.6m stillbirths each year strike middle and low-income countries, they say.
Better clinical care and monitoring could halve stillbirths in poorer countries by 2020, the paper adds.
Save the Children said current opportunities to address the problem were currently being missed.
Invisible toll
The UN's Millennium Development goals set out targets for maternal and child deaths, but the authors of the Lancet reports suggest stillbirths are being neglected, and are taking what they call an "invisible toll" in poorer countries.
Sub-Sahara Africa and South Asian countries continue to suffer the most.
The report tasks poorer countries with reducing still births by 50% by the end of the decade and sets out measures which can be taken.
"Care at birth will give us the biggest return and saves mothers, newborns and children," Dr Joy Lawn of Save the Children told the BBC.
"Another really missed opportunity is treating syphilis during pregnancy and particularly in southern Africa, syphilis still kills babies and we estimate that around 136,000 stillbirths could be averted every year and that's at relatively low cost - it's about making your antenatal clinic services work.
"Other critical things would be treating hypertension in pregnancy, identifying diabetes in women who are pregnant and managing that better and then identifying babies that aren't growing well."
Some countries are already showing the way forward, according to the report.
Middle-income countries such as Columbia, China, Mexico and Argentina, have reduced their stillbirth rates by 40% to 50% in recent years.

'Premature birth gene' discovered

premature babyPremature birth can be dangerous for the baby

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A gene linked to premature births has been discovered by scientists in the US and Finland.
The researchers hope their study, published in PLoS Genetics, could eventually lead to a test for women at risk of a pre-term birth.
In the UK, one in 10 babies are born before the 37th week of pregnancy, with potential problems for their health.
The Royal College of Obstetricians and Gynaecologists said it would help to identify a percentage of those at risk.
The international team of researchers looked to human evolution in their hunt for genes linked to premature births.
In comparison to other primates and mammals, humans have relatively large heads and narrow birth canals.
Acceleration
The researchers, at Vanderbilt University, Washington University and the University of Helsinki, believed there must have been an evolutionary pressure to "adapt and shift the time of birth" to produce a smaller baby.

Risks for premature babies

  • Respiratory distress syndrome
  • Hypothermia
  • Low blood glucose
  • Jaundice
  • Infection
  • Retinopathy of prematurity
  • Necritising enterocolitis
  • Death
They looked for DNA which showed evidence of "accelerated evolution" - genes which have mutated more in humans than in other primates.
They identified 150 genes.
The next step was to look for an association with premature births, so the researchers compared those 150 genes in 328 Finnish mothers, some of whom had premature births.
A strong association to pre-term births was found in variants of the FSHR - or follicle stimulating hormone receptor - gene.
Follicle stimulating hormone acts on receptors in the ovaries to encourage follicle (a sphere of cells containing an egg) development and production of the hormone oestrogen.
'Greatest risk'
Professor Louis Muglia, from the department of paediatrics at Vanderbilt University, said: "Ideally we'd like to predict which women are at greatest risk for having pre-term birth and be able to prevent it. That would really have an impact on infant mortality and the long-term complications of being born prematurely."
Professor Ronald Lamont, spokesperson for the Royal College of Obstetricians and Gynaecologists, said: "I think it's fantastic, it's a good group of well respected people doing this research."
He said the risk of premature birth was likely to be a mix of genetic and environmental factors.
"In the future we will be able to identify a percentage of people at risk. It won't be the be all and end all, but it will contribute to our knowledge."
In a separate study, a team at Washington State University believe they have identified why eggs are produced which result in miscarriage and birth defects.
The research published in Current Biology examines the relationship between eggs and the correct number of chromosomes.

TeloVac pancreatic cancer vaccine trial launched in UK


How does the pancreatic cancer vaccine work?

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A trial has begun on a vaccine treating pancreatic cancer, which has the lowest survival rate of all common cancers.
More than 1,000 patients with advanced pancreatic cancer have joined the TeloVac trial at 53 UK hospitals.
Vaccines are usually associated with preventing infections, but this is part of a new approach to try to stimulate the immune system to fight cancer.
The trial involves regular doses of vaccine together with chemotherapy and compares this with chemotherapy alone.
The vaccine contains small sections of a protein, telomerase, which is over-produced by cancer cells. The aim is to stimulate the immune system to recognise the telomerase which sits on the surface of the cancer cells and to target the tumour.

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For someone who's never smoked and hardly ever drank, it was a big shock”
Rhona LongworthPatient
Professor John Neoptolemos from Royal Liverpool University Hospital, who is helping to co-ordinate the trial, said: "The problem is tumours are clever and are able to turn the immune cells into traitors which help to guard the tumour.
"The vaccine takes away the masking effect of the tumour."
Pancreatic cancer has the worst survival rate of all common cancers. Just three in 100 patients survive the disease for five years or more.
Rhona Longworth, 43, who was diagnosed with the cancer in February, said: "For someone who's never smoked and hardly ever drank, it was a big shock.
"I just hope the vaccine works and I'm one person who goes on to live a happy, healthy life after this."
Joan Roberts, 69, said the vaccine appeared to have few side effects and she is keeping her fingers crossed about the impact on her cancer.
"I'm pleased that it's stable and it hasn't got any bigger. You've got to remain positive," she said.

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There is rarely positive news about pancreatic cancer. It has the worst survival rate of all common cancers - worse even than lung cancer”
The TeloVac trial is being funded by Cancer Research UK. The charity is supporting trials against a range of cancers, using vaccines or antibody treatments to stimulate the immune system.
Cancer Research UK's chief clinician Professor Peter Johnson said: "One of big problems with cancer treatment is you are almost always left with a few malignant cells and it is from those few cells that the cancer can regrow.
"If you can programme the immune system to recognise those cells and get rid of them altogether or keep them in check then you can effectively stop the cancer from growing back lifelong."
The South Korean manufacturer of the vaccine, KAEL-GemVax, is planning a lung cancer trial later this year using the same technology.
Last year the first therapeutic cancer vaccine was licensed in the US as a treatment against prostate cancer.
The Phase III or final stage TeloVac trial should produce results in just over a year which will show whether the vaccine has a positive effect.
Cancer Research UK is keen to stress that the vaccine is not a cure, but if it works, might prolong life.


Language universality idea tested with biology method

Language brain centres during MRIThestudy challenges th idea that the "language centres" of our brains are the sole driver of language

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A long-standing idea that human languages share universal features that are dictated by human brain structure has been cast into doubt.
A study reported in Nature has borrowed methods from evolutionary biology to trace the development of grammar in several language families.
The results suggest that features shared across language families evolved independently in each lineage.
The authors say cultural evolution, not the brain, drives language development.
At the heart of both studies is a method based on what are known as phylogenetic studies.
Lead author Michael Dunn, an evolutionary linguist at the Max Planck Institute for Psycholinguistics in the Netherlands, said the approach is akin to the study of pea plants by Gregor Mendel, which ultimately led to the idea of heritability of traits.
"By looking at variation amongst the descendant plants and knowing how they were related to each other, [Mendel] could work out the mechanisms that must govern that variation," Dr Dunn explained to BBC News.
"He inferred the existence of some kind of information transfer just from knowing family trees and observing variation, and that's exactly the same thing we're doing."
Family trees
Modern phylogenetics studies look at variations in animals that are known to be related, and from those can work out when specific structures evolved.
For their studies, the team studied the characteristics of word order in four language families: Indo-European, Uto-Aztec, Bantu and Austronesian.
They considered whether what we call prepositions occur before or after a noun ("in the boat" versus "the boat in") and how the word order of subject and object work out in either case ("I put the dog in the boat" versus "I the dog put the canoe in").
The method starts by making use of well-established linguistic data on words and grammar within these language families, and building "family trees" of those languages.
"Once we have those trees we look at distribution of these different word order features over the descendant languages, and build evolutionary models for what's most likely to produce the diversity that we observe in the world," Dr Dunn said.
Pea plants in a greenhouseThe methods use inference in a similar way to Mendel's studies of pea plants
The results showed that, although grammatical features were shared across the families, the way that the features arose depended strongly on the history of development of language features within the families.
In a parallel to convergent evolution in biology - in which analogous structures in unrelated animals can evolve independently - grammatical constructs follow their own independent evolutionary paths.
"We show that each of these language families evolves according to its own set of rules, not according to a universal set of rules," Dr Dunn explained.
"That is inconsistent with the dominant 'universality theories' of grammar; it suggests rather that language is part of not a specialised module distinct from the rest of cognition, but more part of broad human cognitive skills."
The paper asserts instead that "cultural evolution is the primary factor that determines linguistic structure, with the current state of a linguistic system shaping and constraining future states".
However, co-author and evolutionary biologist Russell Gray of the University of Auckland stressed that the team was not pitting biology against culture in a mutually exclusive way.
"We're not saying that biology is irrelevant - of course it's not," Professor Gray told BBC News.
"But the clumsy argument about an innate structure of the human mind imposing these kind of 'universals' that we've seen in cognitive science for such a long time just isn't tenable."
Steven Pinker, a cognitive scientist at Harvard University, called the work "an important and welcome study".
However, Professor Pinker told BBC News that the finer details of the method need bearing out in order to more fully support their hypothesis that cultural boundaries drive the development of language more than biological limitations do.
"The [authors] suggest that the human mind has a tendency to generalise orderings across phrases of different types, which would not occur if the mind generated every phrase type with a unique and isolated rule.
"The tendency may be partial, and it may be elaborated in different ways in differently language families, but it needs an explanation in terms of the working of the mind of language speakers."


Dinosaurs were active both day and night, study claims

Juravenator starki fossil (L Schmitz)Small carnivorous dinosaurs like Juravenator starki were nocturnal

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Some dinosaurs did their hunting at night, new research suggests.
Studies of the eyes of existing birds and reptiles with different daily activity patterns were compared with similar parts in dinosaur fossils.
The results suggests that small, meat-eating dinosaurs were nocturnal; large, plant-eating dinosaurs tended to forage both during the day and at night.
The Science study also challenges the notion that mammals' nocturnal nature evolved to avoid day-active dinosaurs.
Lars Schmitz and Ryosuke Motani of the University of California Davis have been looking at the eye parts of dinosaurs, and their modern-day descendants the lizards and birds, for a number of years.
They have been trying to determine just how big and how light-sensitive dinosaurs' eyes would have been.
That in turn would be an indication of whether they were active at night; until now the assumption has been that dinosaurs were diurnal, or primarily active in the daytime only.
However, fossils give no indication of how large dinosaurs' pupils would have been - an indication of how much light they could gather up, and thus of whether they were nocturnal "night stalkers".
A prior study in the Journal of Morphology by the pair that showed that the size of the "scleral ring" - a ring of bone that covers the iris and pupil in many animals - is a good indicator of the size of the pupil.
"We measured living lizards and birds to test if you can use these bone parts to distinguish the nocturnals from diurnals," Dr Schmitz explained to BBC News.
"We picked species for which we know their activity patterns - we know if they are nocturnal, diurnal or both - and then we found we could tell them apart [on the basis of their ocular bone sizes].
"Once we had that established we applied what we learned from the living species to the dinosaurs."
The pair measured the eye socket size and scleral ring size of 33 dinosaur fossils, finding that dinosaurs seemed to be busy at a variety of times of day and night.
Scaphognathus crassirostris fossil (L Schmitz)The plant-eating Scaphognathus crassirostris would have foraged day and night to support its size
"Contrary to what was believed - that most dinosaurs were diurnal - we saw pretty much everything: we had diurnal, nocturnal and species active both day and night, that was the first surprise," Dr Schmitz said.
"The activity patterns depend essentially on what they do for a living - what the ecology is. Small carnivores like velociraptor tended to be nocturnal or active day and night; we didn't have a diurnal carnivore in our analysis.
"Large herbivores, they were almost exclusively day- and night-active."
Dr Schmitz said this was probably because larger animals needed to forage longer to support their large sizes.
The find also casts doubt on the idea that mammals - who in modern times are predominantly nocturnal - evolved their activity patterns to avoid being targeted by day-active dinosaurs.
"We now know that dinosaurs were active at night as well, so the whole story is much more complicated," Dr Schmitz said.
"We don't even know if early mammals were truly nocturnal; we have do a lot more research to understand how nocturnality in mammals evolved."


BBC Proms 2011: Tim Minchin concert among highlights

Tim MinchinMinchin co-wrote a musical version of Roald Dahl's novel Matilda, performed at the RSC

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A comedy concert hosted by Tim Minchin, an audience request night and Liszt bicentenary celebrations are among the highlights of this year's BBC Proms.
There will also be a concerto for turntables and orchestra as well as Hollywood film music concerts.
A series of choral Sundays will kick off at the Royal Albert Hall on 17 July with a symphony featuring a Proms record-breaking 1,000-plus performers.
This year's Proms will run from 15 July to 10 September.
Organisers said Liszt piano concertos on the first and last nights of the Proms would serve as "dazzling bookends to the season".
Benjamin Grosvenor will perform on the opening night with Lang Lang playing on the final evening, while a late night prom with Marc-Andre Hamelin will also celebrate Liszt.
Other works by the Hungarian composer to be performed include his Dante and Faust Symphonies and his orchestral Funeral Odes, never before heard at the Proms.

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It will be the first concert to sell out because once you put the performers in there, there is hardly any room for the audience”
BBC Proms director Roger Wright on the mass choral performance of The Gothic
On Friday 2 September, the Budapest Festival Orchestra, conducted by Ivan Fischer, will have "a huge pile of music" on hand to take requests from the audience.
The mass choral performance on 17 July, of Havergal Brian symphony The Gothic, will feature two orchestras and 10 choirs, including Huddersfield Choral Society and the Southend Boys and Girls Choirs.
Mr Wright joked that the piece, dubbed "the largest and longest symphony ever written", would sell out quickly.
"It will be the first concert to sell out because once you put the performers in there, there is hardly any room for the audience," he added.
On Friday 12 August, the BBC Concert Orchestra will play music from films including Harry Potter, Star Wars and Psycho.
There will also be a tribute to Bond composer John Barry and a performance by the Spaghetti Western Orchestra.
Simon Bolivar Symphony Orchestra, conducted by Gustavo DudamelVenezuelan youth ensemble the Simon Bolivar Symphony Orchestra will perform
Meanwhile, Concerto For Turntables, written by Gabriel Prokofiev - grandson of Sergei Prokofiev - will be performed by DJ Switch with the National Youth Orchestra of Great Britain.
Other Proms highlights among the 90 concerts - of which 74 will be in the Royal Albert Hall - include a Nigel Kennedy late night solo Bach recital and the return of Venezuelan youth ensemble the Simon Bolivar Symphony Orchestra, conducted by Gustavo Dudamel.
Performances will be broadcast on Radio 3 as well as on BBC Two and BBC Four throughout the season.
All broadcast proms will be available to view for a further seven days onthe BBC Proms website.